Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

INTRODUCTION: TNFα is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNFα activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFα-regulated gene expre...

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Bibliographic Details
Main Authors: Rockel, Jason S, Bernier, Suzanne M, Leask, Andrew
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688239/
https://ncbi.nlm.nih.gov/pubmed/19144181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2595
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