Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

The regenerative potential diminishes with age and this has been ascribed to functional impairments of adult stem cells. Cells in culture undergo senescence after a certain number of cell divisions whereby the cells enlarge and finally stop proliferation. This observation of replicative senescence h...

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Bibliographische Detailangaben
Hauptverfasser: Wagner, Wolfgang, Bork, Simone, Horn, Patrick, Krunic, Damir, Walenda, Thomas, Diehlmann, Anke, Benes, Vladimir, Blake, Jonathon, Huber, Franz-Xaver, Eckstein, Volker, Boukamp, Petra, Ho, Anthony D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688074/
https://ncbi.nlm.nih.gov/pubmed/19513108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005846
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