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Speeding up HMM algorithms for genetic linkage analysis via chain reductions of the state space
We develop an hidden Markov model (HMM)-based algorithm for computing exact parametric and non-parametric linkage scores in larger pedigrees than was possible before. The algorithm is applicable whenever there are chains of persons in the pedigree with no genetic measurements and with unknown affect...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2687978/ https://ncbi.nlm.nih.gov/pubmed/19477987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp224 |
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