Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF–RARα and NPM–RARα

Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RARα and one of four fusion partners: PML, PLZF, NPM, and NuMA genes. To study the leukemogenic potential of the fusion genes in vivo, we generated transgenic mice with PLZF–RARα and NPM–RARα. PLZF–R...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cheng, G.-X., Zhu, X.-H., Men, X.-Q., Wang, L., Huang, Q.-H., Jin, X. L., Xiong, S.-M., Zhu, J., Guo, W.-M., Chen, J.-Q., Xu, S.-F., So, E., Chan, L.-C., Waxman, S., Zelent, A., Chen, G.-Q., Dong, S., Liu, J.-X., Chen, S.-J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10339585/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.11.6318
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