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Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling
The melanocortin system is crucial to regulation of energy homeostasis. The melanocortin receptor type 4 (MC4R) modulates insulin signaling via effects on c-Jun N-terminal kinase (JNK). The melanocortin agonist NDP-MSH dose-dependently inhibited JNK activity in HEK293 cells stably expressing the hum...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2687409/ https://ncbi.nlm.nih.gov/pubmed/19463742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2009.03.006 |
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