Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

The parvovirus adeno-associated virus (AAV) contains a small single-stranded DNA genome with inverted terminal repeats that form hairpin structures. In order to propagate, AAV relies on the cellular replication machinery together with functions supplied by coinfecting helper viruses such as adenovir...

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Bibliographic Details
Main Authors: Schwartz, Rachel A., Carson, Christian T., Schuberth, Christine, Weitzman, Matthew D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687378/
https://ncbi.nlm.nih.gov/pubmed/19339345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00318-09
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