Protection of Mycobacterium tuberculosis from Reactive Oxygen Species Conferred by the mel2 Locus Impacts Persistence and Dissemination

Persistence of Mycobacterium tuberculosis in humans represents a major roadblock to elimination of tuberculosis. We describe identification of a locus in M. tuberculosis, mel2, that displays similarity to bacterial bioluminescent loci and plays an important role during persistence in mice. We constr...

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Bibliographic Details
Main Authors: Cirillo, Suat L. G., Subbian, Selvakumar, Chen, Bing, Weisbrod, Torin R., Jacobs, William R., Cirillo, Jeffrey D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687327/
https://ncbi.nlm.nih.gov/pubmed/19349422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01481-08
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