Predictive Value of Pharmacokinetics-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PIs) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy

The activities of protease inhibitors in vivo may depend on plasma concentrations and viral susceptibility. This nonrandomized, open-label study evaluated the relationship of the inhibitory quotient (IQ [the ratio of drug exposure to viral phenotypic susceptibility]) to the human immunodeficiency vi...

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Detalhes bibliográficos
Main Authors: Eron, Joseph J., Park, Jeong-Gun, Haubrich, Richard, Aweeka, Francesca, Bastow, Barbara, Pakes, Gary E., Yu, Song, Wu, Hulin, Richman, Douglas D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687257/
https://ncbi.nlm.nih.gov/pubmed/19307363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01387-08
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