Cellular Mechanism of Decreased Bone in Brtl Mouse Model of OI: Imbalance of Decreased Osteoblast Function and Increased Osteoclasts and Their Precursors

The Brtl mouse, a knock-in model for moderately severe osteogenesis imperfecta (OI), has a G349C substitution in half of type I collagen α1(I) chains. We studied the cellular contribution to Brtl bone properties. Brtl cortical and trabecular bone are reduced before and after puberty, with BV/TV decr...

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Bibliographische Detailangaben
Hauptverfasser: Uveges, Thomas E, Collin-Osdoby, Patricia, Cabral, Wayne A, Ledgard, Felicia, Goldberg, Leah, Bergwitz, Clemens, Forlino, Antonella, Osdoby, Philip, Gronowicz, Gloria A, Marini, Joan C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Amer Soc Bone & Mineral Res. 2008
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686922/
https://ncbi.nlm.nih.gov/pubmed/18684089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080804
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