Alendronate Treatment of the Brtl Osteogenesis Imperfecta Mouse Improves Femoral Geometry and Load Response Before Fracture but Decreases Predicted Material Properties and Has Detrimental Effects on Osteoblasts and Bone Formation

Long courses of bisphosphonates are widely administered to children with osteogenesis imperfecta (OI), although bisphosphonates do not block mutant collagen secretion and may affect bone matrix composition or structure. The Brtl mouse has a glycine substitution in col1a1 and is ideal for modeling th...

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Detaylı Bibliyografya
Asıl Yazarlar: Uveges, Thomas E., Kozloff, Kenneth M., Ty, Jennifer M., Ledgard, Felicia, Raggio, Cathleen L., Gronowicz, Gloria, Goldstein, Steven A., Marini, Joan C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Amer Soc Bone & Mineral Res. 2009
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Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672204/
https://ncbi.nlm.nih.gov/pubmed/19113917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.081238
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