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Distinct phosphorylation requirements regulate cortactin activation by Tir(EPEC )and its binding to N-WASP

BACKGROUND: Cortactin activates the actin-related 2/3 (Arp2/3) complex promoting actin polymerization to remodel cell architecture in multiple processes (e.g. cell migration, membrane trafficking, invadopodia formation etc.). Moreover, it was called the Achilles' heel of the actin cytoskeleton...

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Detalhes bibliográficos
Main Authors: Nieto-Pelegrin, Elvira, Martinez-Quiles, Narcisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686683/
https://ncbi.nlm.nih.gov/pubmed/19419567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-7-11
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