IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation

Reports that follicular dendritic cells (FDCs) produce IL-6 prompted the hypotheses that immune complexes (ICs) induce FDCs to produce IL-6 and that FDC–IL-6 promotes germinal center (GC) reactions, somatic hypermutation (SHM) and IgG production. FDCs were activated in vitro by addition of ICs and F...

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Detalhes bibliográficos
Main Authors: Wu, Yongzhong, El Shikh, Mohey Eldin M., El Sayed, Rania M., Best, Al M., Szakal, Andras K., Tew, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Original Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686616/
https://ncbi.nlm.nih.gov/pubmed/19461124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp041
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