Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3(+) regulatory T cells allows for their purification from expansion cultures

Although adoptive transfer of regulatory T cells (Foxp3(+) Tregs) has proven to be efficacious in the prevention and treatment of autoimmune diseases and graft-versus-host disease in rodents, a major obstacle for the use of Treg immunotherapy in humans is the difficulty of obtaining a highly purifie...

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Detalhes bibliográficos
Main Authors: Tran, Dat Q., Andersson, John, Hardwick, Donna, Bebris, Lolita, Illei, Gabor G., Shevach, Ethan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686183/
https://ncbi.nlm.nih.gov/pubmed/19299332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-199950
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