Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Overexpression of methylguanine methyltransferase P140K (MGMTP140K) has been successfully used for in vivo selection and chemoprotection in mouse and large animal studies, and has promise for autologous and allogeneic gene therapy. We examined the long-term safety of MGMTP140K selection in a clinica...

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Detalhes bibliográficos
Main Authors: Beard, Brian C., Sud, Reeteka, Keyser, Kirsten A., Ironside, Christina, Neff, Tobias, Gerull, Sabine, Trobridge, Grant D., Kiem, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686180/
https://ncbi.nlm.nih.gov/pubmed/19336761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-176412
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