Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

Overexpression of methylguanine methyltransferase P140K (MGMTP140K) has been successfully used for in vivo selection and chemoprotection in mouse and large animal studies, and has promise for autologous and allogeneic gene therapy. We examined the long-term safety of MGMTP140K selection in a clinica...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Beard, Brian C., Sud, Reeteka, Keyser, Kirsten A., Ironside, Christina, Neff, Tobias, Gerull, Sabine, Trobridge, Grant D., Kiem, Hans-Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2009
Aiheet:
Gene Therapy
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686180/
https://ncbi.nlm.nih.gov/pubmed/19336761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-176412
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