Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

BACKGROUND: Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. METHODOLOGY/PRINCIPA...

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Main Authors: Gispert, Suzana, Ricciardi, Filomena, Kurz, Alexander, Azizov, Mekhman, Hoepken, Hans-Hermann, Becker, Dorothea, Voos, Wolfgang, Leuner, Kristina, Müller, Walter E., Kudin, Alexei P., Kunz, Wolfram S., Zimmermann, Annabelle, Roeper, Jochen, Wenzel, Dirk, Jendrach, Marina, García-Arencíbia, Moisés, Fernández-Ruiz, Javier, Huber, Leslie, Rohrer, Hermann, Barrera, Miguel, Reichert, Andreas S., Rüb, Udo, Chen, Amy, Nussbaum, Robert L., Auburger, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686165/
https://ncbi.nlm.nih.gov/pubmed/19492057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005777
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