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Ligand Selectivity of D(2) Dopamine Receptors Is Modulated by Changes in Local Dynamics Produced by Sodium Binding
We have uncovered a significant allosteric response of the D(2) dopamine receptor to physiologically relevant concentrations of sodium (140 mM), characterized by a sodium-enhanced binding affinity for a D(4)-selective class of agonists and antagonists. This enhancement is significantly more pronounc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685898/ https://ncbi.nlm.nih.gov/pubmed/18849360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.141531 |
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