Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA

Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the disease show reduction or loss of E-cadherin expression, but recovery of its expression is frequently found at advanced phases. We overexpress...

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Bibliografiske detaljer
Main Authors: Molina-Ortiz, Isabel, Bartolomé, Rubén A., Hernández-Varas, Pablo, Colo, Georgina P., Teixidó, Joaquin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685696/
https://ncbi.nlm.nih.gov/pubmed/19293150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807834200
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