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Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA

Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the disease show reduction or loss of E-cadherin expression, but recovery of its expression is frequently found at advanced phases. We overexpress...

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Detalhes bibliográficos
Main Authors: Molina-Ortiz, Isabel, Bartolomé, Rubén A., Hernández-Varas, Pablo, Colo, Georgina P., Teixidó, Joaquin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685696/
https://ncbi.nlm.nih.gov/pubmed/19293150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807834200
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