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Ionizing Radiation Induces ATM-independent Degradation of p21(Cip1) in Transformed Cells
The cyclin-dependent kinase inhibitor p21(Cip1) plays an important role in the cellular response to DNA damage. In normal cells, genotoxic stress activates the ATM-p53 pathway that up-regulates the expression of p21(Cip1) leading to cell cycle arrest. However, we have found that in several neoplasti...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685688/ https://ncbi.nlm.nih.gov/pubmed/19332548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808810200 |
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