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Identification and Manipulation of the Caprazamycin Gene Cluster Lead to New Simplified Liponucleoside Antibiotics and Give Insights into the Biosynthetic Pathway

Caprazamycins are potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. MK730-62F2 and belong to the translocase I inhibitor family. Their complex structure is derived from 5′-(β-O-aminoribosyl)-glycyluridine and comprises a unique N-methyldiazepanone ring. The biosynth...

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Bibliografski detalji
Glavni autori: Kaysser, Leonard, Lutsch, Liane, Siebenberg, Stefanie, Wemakor, Emmanuel, Kammerer, Bernd, Gust, Bertolt
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685681/
https://ncbi.nlm.nih.gov/pubmed/19351877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901258200
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