Heterologous Expression of Novobiocin and Clorobiocin Biosynthetic Gene Clusters

A method was developed for the heterologous expression of biosynthetic gene clusters in different Streptomyces strains and for the modification of these clusters by single or multiple gene replacements or gene deletions with unprecedented speed and versatility. λ-Red-mediated homologous recombinatio...

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Bibliographic Details
Main Authors: Eustáquio, Alessandra S., Gust, Bertolt, Galm, Ute, Li, Shu-Ming, Chater, Keith F., Heide, Lutz
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087579/
https://ncbi.nlm.nih.gov/pubmed/15870333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.5.2452-2459.2005
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