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Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression
In mammalian cells, microRNAs (miRNAs) are incorporated into miRNA-induced silencing complexes (miRISCs), which regulate protein expression post-transcriptionally through binding to 3′-untranslated regions of target mRNAs. Argonaute2 (Ago2), a key component of the miRISC, recruits GW182, a component...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685530/ https://ncbi.nlm.nih.gov/pubmed/19398495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1363109 |
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