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Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy

BACKGROUND: The COP9/signalosome (CSN) is a highly conserved eight subunit complex that, by deneddylating cullins in cullin-based E3 ubiquitin ligases, regulates protein degradation. Although studied in model human cell lines such as HeLa, very little is known about the role of the CSN in haemopoiet...

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Autors principals: Pearce, Claire, Hayden, Rachel E, Bunce, Christopher M, Khanim, Farhat L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685372/
https://ncbi.nlm.nih.gov/pubmed/19400951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-31
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