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Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability
BACKGROUND: The COP9 signalosome (CSN) is a conserved protein complex in eukaryotic cells consisting of eight subunits (CSN1 to CSN8). Recent data demonstrate that the CSN is a regulator of the ubiquitin (Ub) proteasome system (UPS). It controls substrate ubiquitination by cullin-RING Ub ligases (CR...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2225408/ https://ncbi.nlm.nih.gov/pubmed/18093314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-8-27 |
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