Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability

BACKGROUND: The COP9 signalosome (CSN) is a conserved protein complex in eukaryotic cells consisting of eight subunits (CSN1 to CSN8). Recent data demonstrate that the CSN is a regulator of the ubiquitin (Ub) proteasome system (UPS). It controls substrate ubiquitination by cullin-RING Ub ligases (CR...

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Main Authors: Peth, Andreas, Berndt, Christoph, Henke, Wolfgang, Dubiel, Wolfgang
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225408/
https://ncbi.nlm.nih.gov/pubmed/18093314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-8-27
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