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Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice

Human failing hearts exhibit significant decreases in junctin expression levels with almost nondetectable levels, which may be associated with premature death, induced by lethal cardiac arrhythmias, based on mouse models. However, the specific contribution of junctin to the delayed afterdepolarizati...

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Detalhes bibliográficos
Main Authors: Yuan, Qunying, Han, Peidong, Dong, Min, Ren, Xiaoping, Zhou, Xiaoyang, Chen, Shan, Jones, W. Keith, Chu, Guoxiang, Wang, Hong-Sheng, Kranias, Evangelia G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685343/
https://ncbi.nlm.nih.gov/pubmed/19286959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00229.2008
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