Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function

In nonphagocytic cells, Rac1 is a component of NADPH oxidase that produces reactive oxygen species [Ushio-Fukai M (2006) Sci STKE 2006:re8]. Rac1 is expressed abundantly in mammalian retinal photoreceptors, where it is activated in response to light stimuli [Balasubramanian N, Slepak VZ (2003) Curr...

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Bibliographische Detailangaben
Hauptverfasser: Haruta, Masatoshi, Bush, Ronald A., Kjellstrom, Sten, Vijayasarathy, Camasamudram, Zeng, Yong, Le, Yun-Zheng, Sieving, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685247/
https://ncbi.nlm.nih.gov/pubmed/19470639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808940106
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