Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome

PURPOSE: To test the effects of rearing light intensity on retinal function and morphology in the retinoschisis knockout (Rs1-KO) mouse model of X-linked retinoschisis, and whether it affects functional outcome of RS1 gene replacement. METHODS: Seventy-six Rs1-KO mice were reared in either cyclic lo...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Marangoni, Dario, Yong, Zeng, Kjellström, Sten, Vijayasarathy, Camasamudram, A. Sieving, Paul, Bush, Ronald A.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2017
Subjects:
Retina
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361586/
https://ncbi.nlm.nih.gov/pubmed/28297725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-21016
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