Synaptic Pathology in Retinoschisis Knockout (Rs1(−)(/y)) Mouse Retina and Modification by rAAV-Rs1 Gene Delivery

PURPOSE: At an early age, the retinoschisin knockout (Rs1-KO) mouse retina has progressive photoreceptor degeneration with severe disruption of the outer plexiform layer (OPL) that decreases at older ages. The electroretinogram (ERG) undergoes parallel changes. The b-wave amplitude from bipolar cell...

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Détails bibliographiques
Auteurs principaux: Takada, Yuichiro, Vijayasarathy, Camasamudram, Zeng, Yong, Kjellstrom, Sten, Bush, Ronald A., Sieving, Paul A.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556260/
https://ncbi.nlm.nih.gov/pubmed/18660429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1071
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