Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

Small RNAs targeted to gene promoters in human cells can mediate transcriptional gene silencing (TGS) by directing silent state epigenetic modifications to targeted loci. Many mechanistic details of this process remain poorly defined, and the ability to stably modulate gene expression in this manner...

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Bibliografiske detaljer
Main Authors: Hawkins, Peter G., Santoso, Sharon, Adams, Christopher, Anest, Vasiliki, Morris, Kevin V.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685082/
https://ncbi.nlm.nih.gov/pubmed/19304753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp127
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