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Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

Small RNAs targeted to gene promoters in human cells can mediate transcriptional gene silencing (TGS) by directing silent state epigenetic modifications to targeted loci. Many mechanistic details of this process remain poorly defined, and the ability to stably modulate gene expression in this manner...

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Autori principali: Hawkins, Peter G., Santoso, Sharon, Adams, Christopher, Anest, Vasiliki, Morris, Kevin V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685082/
https://ncbi.nlm.nih.gov/pubmed/19304753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp127
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