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Estimation of Relative Microscopic Affinity Constants of Agonists for the Active State of the Receptor in Functional Studies on M(2) and M(3) Muscarinic Receptors

In prior work, we have shown that it is possible to estimate the product of observed affinity and intrinsic efficacy of an agonist expressed relative to that of a standard agonist simply through the analysis of their respective concentration-response curves. In this report, we show analytically and...

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Bibliografiset tiedot
Päätekijät: Tran, John A., Chang, Alexander, Matsui, Minoru, Ehlert, Frederick J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Pharmacology and Experimental Therapeutics 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684900/
https://ncbi.nlm.nih.gov/pubmed/18996972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.051276
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