Bifunctional DNA Alkylator 1,3-Bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway

The presence of DNA damage initiates signaling through the ataxia-telangiectasia mutated kinase (ATM) and the ATM- and the Rad3-related kinase (ATR), which phosphorylate, thus activating, the checkpoint kinases (Chk) 1 and 2, which leads to cell cycle arrest. The bifunctional DNA alkylator 1,3-bis(2...

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Bibliographic Details
Main Authors: Cui, B., Johnson, S. P., Bullock, N., Ali-Osman, F., Bigner, D. D., Friedman, H. S.
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684885/
https://ncbi.nlm.nih.gov/pubmed/19261750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053124
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