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An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus

Nematode glutamate-gated chloride channels are targets of the macrocyclic lactones, the most important group of anthelmintics available. In Xenopus laevis oocytes, channels formed by the GluClα3B subunit from the parasite Haemonchus contortus were more sensitive to l-glutamate (EC(50) = 27.6 ± 2.7 μ...

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Main Authors: McCavera, Samantha, Rogers, Adrian T., Yates, Darran M., Woods, Debra J., Wolstenholme, Adrian J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Pharmacology and Experimental Therapeutics 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684884/
https://ncbi.nlm.nih.gov/pubmed/19336526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053363
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