Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis

The Erbb2 receptor is activated by UV irradiation, the primary cause of non-melanoma skin cancer. We hypothesized that Erbb2 activation contributes to UV-induced skin tumorigenesis by suppressing cell cycle arrest. Consistent with this hypothesis, inhibition of Erbb2 in v-ras(Ha) transgenic mice bef...

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Autors principals: Madson, Justin G., Lynch, David T., Svoboda, Jessica, Ophardt, Rebecca, Yanagida, Jodi, Putta, Sumanth K., Bowles, Andrew, Trempus, Carol S., Tennant, Raymond W., Hansen, Laura A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684199/
https://ncbi.nlm.nih.gov/pubmed/19406993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080638
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