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BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and acetylated BubR1-specific antibodies, we have confirmed that BubR1 acetylation occurs at prometaphase. Importantly, BubR1 a...

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מידע ביבליוגרפי
Main Authors: Choi, Eunhee, Choe, Hyerim, Min, Jaewon, Choi, Ji Yoon, Kim, Jimi, Lee, Hyunsook
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684026/
https://ncbi.nlm.nih.gov/pubmed/19407811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.123
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