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BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and acetylated BubR1-specific antibodies, we have confirmed that BubR1 acetylation occurs at prometaphase. Importantly, BubR1 a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684026/ https://ncbi.nlm.nih.gov/pubmed/19407811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.123 |
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