Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy

Based on promising pre-clinical data demonstrating the eradication of systemic B cell malignancies by CD19-targeted T lymphocytes in vivo in SCID beige mouse models, we are launching Phase 1 clinical trials in patients with chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). W...

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Detalhes bibliográficos
Main Authors: Hollyman, Daniel, Stefanski, Jolanta, Przybylowski, Mark, Bartido, Shirley, Borquez-Ojeda, Oriana, Taylor, Clare, Yeh, Raymond, Capacio, Vanessa, Olszewska, Malgorzata, Hosey, James, Sadelain, Michel, Brentjens, Renier J., Rivière, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683970/
https://ncbi.nlm.nih.gov/pubmed/19238016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e318194a6e8
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