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Phenobarbital Elicits Unique, Early Changes in the Expression of Hepatic Genes that Affect Critical Pathways in Tumor-Prone B6C3F1 Mice

At 2 and 4 weeks following treatment with phenobarbital (PB), the classical nongenotoxic rodent liver carcinogen, we elucidated unique gene expression changes (both induction and repression) in liver tumor-susceptible B6C3F1 mice, as compared with the relatively resistant C57BL/6. Based on their can...

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Bibliographic Details
Main Authors: Phillips, Jennifer M., Burgoon, Lyle D., Goodman, Jay I.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683922/
https://ncbi.nlm.nih.gov/pubmed/19270015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp050
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