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Multiple Genes Exhibit Phenobarbital-Induced Constitutive Active/Androstane Receptor–Mediated DNA Methylation Changes during Liver Tumorigenesis and in Liver Tumors

The constitutive active/androstane receptor (CAR) mediates responses to the nongenotoxic rodent liver tumor promoter phenobarbital (PB), including certain gene expression changes, hepatomegaly, and tumor formation. Aberrant DNA methylation represents epigenetic events that can play multiple roles in...

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Detalhes bibliográficos
Main Authors: Phillips, Jennifer M., Goodman, Jay I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664694/
https://ncbi.nlm.nih.gov/pubmed/19233941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp031
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