Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities

Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases (UGTs). This study aims to further understand the functions of UGT in metabolizing genistein and apigenin, two compounds metabolized more extensively in the gut than in the liver. Because Gunn rats...

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Autors principals: Wang, Stephen W. J., Kulkarni, Kaustubh H., Tang, Lan, Wang, Jing Rong, Yin, Taijun, Daidoji, Tomo, Yokota, Hiroshi, Hu, Ming
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683779/
https://ncbi.nlm.nih.gov/pubmed/19264971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.147371
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