Disposition of Flavonoids via Enteric Recycling: Enzyme Stability Affects Characterization of Prunetin Glucuronidation across Species, Organs, and UGT Isoforms

We characterized the in vitro glucuronidation of prunetin, a prodrug of genistein that is a highly active cancer prevention agent. Metabolism studies were conducted using expressed human UGT isoforms and microsomes/S9 fractions prepared from intestine and liver of rodents and humans. The results ind...

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Bibliographic Details
Main Authors: Joseph, Tiby B., Wang, Stephen W.J., Liu, Xing, Kulkarni, Kaustubh H., Wang, Jingrong, Xu, Haiyan, Hu, Ming
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532587/
https://ncbi.nlm.nih.gov/pubmed/18052087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp700135a
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