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Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection

For currently unknown reasons, the evolution of CYP3A4 underwent acceleration in the human lineage after the split from chimpanzee. We investigated the significance of this event by comparing Escherichia coli-expressed CYP3A4 from humans, chimpanzee, and their most recent common ancestor. The expres...

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Detalhes bibliográficos
Main Authors: Kumar, Santosh, Qiu, Huan, Oezguen, Numan, Herlyn, Holger, Halpert, James R., Wojnowski, Leszek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683693/
https://ncbi.nlm.nih.gov/pubmed/19299527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.024372
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