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Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection

For currently unknown reasons, the evolution of CYP3A4 underwent acceleration in the human lineage after the split from chimpanzee. We investigated the significance of this event by comparing Escherichia coli-expressed CYP3A4 from humans, chimpanzee, and their most recent common ancestor. The expres...

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Bibliografski detalji
Glavni autori: Kumar, Santosh, Qiu, Huan, Oezguen, Numan, Herlyn, Holger, Halpert, James R., Wojnowski, Leszek
Format: Artigo
Jezik:Inglês
Izdano: American Society for Pharmacology and Experimental Therapeutics 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683693/
https://ncbi.nlm.nih.gov/pubmed/19299527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.024372
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