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Identification and Analysis of Conserved Sequence Motifs in Cytochrome P450 Family 2: FUNCTIONAL AND STRUCTURAL ROLE OF A MOTIF (187)RFDYKD(192) IN CYP2B ENZYMES

Using a multiple alignment of 175 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with the program PCPMer. Functional importance of the CSM in CYP2B enzymes was assessed from available data on site-directed mutants and genetic variants. These analyses su...

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Detalhes bibliográficos
Main Authors: Oezguen, Numan, Kumar, Santosh, Hindupur, Aditya, Braun, Werner, Muralidhara, B. K., Halpert, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490781/
https://ncbi.nlm.nih.gov/pubmed/18495666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708582200
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