Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice

Vitamin D receptor (VDR) mediates vitamin D signaling involved in bone metabolism, cellular growth and differentiation, cardiovascular function, and bile acid regulation. Mice with an intestine-specific disruption of VDR (Vdr(ΔIEpC)) have abnormal body size, colon structure, and imbalance of bile ac...

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Detalhes bibliográficos
Main Authors: Cheng, Jie, Fang, Zhong-Ze, Kim, Jung-Hwan, Krausz, Kristopher W., Tanaka, Naoki, Chiang, John Y. L., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934730/
https://ncbi.nlm.nih.gov/pubmed/24343899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M044420
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