The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation

The pregnane X receptor (PXR; PXR.1) can be activated by structurally diverse lipophilic ligands. PXR.2, an alternatively spliced form of PXR, lacks 111 nucleotides encoding 37 amino acids in the ligand binding domain. PXR.2 bound a classic CYP3A4 PXR response element (PXRE) in electrophoretic mobil...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lin, Yvonne S., Yasuda, Kazuto, Assem, Mahfoud, Cline, Cynthia, Barber, Joe, Li, Chia-Wei, Kholodovych, Vladyslav, Ai, Ni, Chen, J. Don, Welsh, William J., Ekins, Sean, Schuetz, Erin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683691/
https://ncbi.nlm.nih.gov/pubmed/19251824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.025213
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados