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Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts

The pregnane X receptor (PXR) regulates the metabolism and elimination of bile salts, steroids, and xenobiotics. The sequence of the PXR ligand-binding domain diverges extensively between different animals suggesting inter-species differences in ligands. Of the endogenous ligands known to activate P...

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Détails bibliographiques
Auteurs principaux: Krasowski, Matthew D., Yasuda, Kazuto, Hagey, Lee R., Schuetz, Erin G.
Format: Artigo
Langue:Inglês
Publié: 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2238640/
https://ncbi.nlm.nih.gov/pubmed/15718292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2004-0427
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