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Evolution of the pregnane X receptor: adaptation to cross-species differences in biliary bile salts
The pregnane X receptor (PXR) regulates the metabolism and elimination of bile salts, steroids, and xenobiotics. The sequence of the PXR ligand-binding domain diverges extensively between different animals suggesting inter-species differences in ligands. Of the endogenous ligands known to activate P...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2238640/ https://ncbi.nlm.nih.gov/pubmed/15718292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2004-0427 |
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