טוען...
Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
Valproic acid (VPA) is a widely used anticonvulsant that is also approved for mood disorders, bipolar depression, and migraine. In vivo, valproate is metabolized oxidatively by cytochromes P450 and β-oxidation, as well as conjugatively via glucuronidation. The acyl glucuronide conjugate (valproate-g...
שמור ב:
| Main Authors: | , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683660/ https://ncbi.nlm.nih.gov/pubmed/18838507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022426 |
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