IL-2 and Antigen Dose Differentially Regulate Perforin- and FasL-Mediated Cytolytic Activity in Antigen Specific CD4(+) T Cells

CD4 T cell effectors can promote survival against lethal influenza virus via perforin mediated cytolytic mechanisms, however; our understanding of how naïve CD4 cells differentiate into class II restricted killers remains obscure. To address this, TCR Tg CD4 cells were activated in vitro and examine...

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Main Authors: Brown, Deborah M., Kamperschroer, Cris, Dilzer, Allison M., Roberts, Deborah M., Swain, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683476/
https://ncbi.nlm.nih.gov/pubmed/19338979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2009.03.002
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