Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Activation of self-reactive CD8(+) T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3(+) TCR-αβ(+) CD4(-) CD8(-)) T cells that have been proposed to derive from CD8(+) c...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Flores-Mendoza, Giovanna, Rodríguez-Rodríguez, Noé, Rubio, Rosa M., Madera-Salcedo, Iris K., Rosetti, Florencia, Crispín, José C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024570/
https://ncbi.nlm.nih.gov/pubmed/33841416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.635862
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